BDBM50214577 4'-(6,7-dimethoxy-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol::4'-(6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)biphenyl-4-ol::4'-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol::CHEMBL245796::Chk1_115

SMILES COc1cc2Cc3c(n[nH]c3-c2cc1OC)-c1ccc(cc1)-c1ccc(O)cc1

InChI Key InChIKey=VXNCNVGVUUUFPK-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50214577   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50214577(4'-(6,7-dimethoxy-1,4-dihydro-indeno[1,2-c]pyrazol...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50214577(4'-(6,7-dimethoxy-1,4-dihydro-indeno[1,2-c]pyrazol...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of recombinant CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50214577(4'-(6,7-dimethoxy-1,4-dihydro-indeno[1,2-c]pyrazol...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50214577(4'-(6,7-dimethoxy-1,4-dihydro-indeno[1,2-c]pyrazol...)
Affinity DataIC50:  2nMAssay Description:Abbott Kinase Enzymatics_CHK1/289 CDC25c - IC50(uM) (IC50)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50214577(4'-(6,7-dimethoxy-1,4-dihydro-indeno[1,2-c]pyrazol...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed