BDBM50215989 CHEMBL392232::cis-N-(1-methyl-4-(5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)piperidin-3-yl)-4-((2-methylquinolin-4-yl)methoxy)benzamide

SMILES CN1CC[C@@H]([C@@H](C1)NC(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)c1n[nH]c(=S)[nH]1

InChI Key InChIKey=HOQRRVLBMMILPN-JTHBVZDNSA-N

Data  5 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50215989   

TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50215989(CHEMBL392232 | cis-N-(1-methyl-4-(5-thioxo-4,5-dih...)
Affinity DataKi:  958nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50215989(CHEMBL392232 | cis-N-(1-methyl-4-(5-thioxo-4,5-dih...)
Affinity DataKi: >3.33E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50215989(CHEMBL392232 | cis-N-(1-methyl-4-(5-thioxo-4,5-dih...)
Affinity DataKi: >4.50E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50215989(CHEMBL392232 | cis-N-(1-methyl-4-(5-thioxo-4,5-dih...)
Affinity DataKi: >5.03E+3nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50215989(CHEMBL392232 | cis-N-(1-methyl-4-(5-thioxo-4,5-dih...)
Affinity DataKi:  5.37E+3nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50215989(CHEMBL392232 | cis-N-(1-methyl-4-(5-thioxo-4,5-dih...)
Affinity DataIC50:  16nMAssay Description:Inhibition of porcine TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed