BDBM50216276 (-)-dihydroguaiaretic acid::4,4'-((2R,3R)-2,3-dimethylbutane-1,4-diyl)bis(2-methoxyphenol)::CHEMBL375927

SMILES COc1cc(C[C@@H](C)[C@H](C)Cc2ccc(O)c(OC)c2)ccc1O

InChI Key InChIKey=ADFOLUXMYYCTRR-ZIAGYGMSSA-N

Data  6 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50216276   

TargetCarbonic anhydrase(Candida albicans (Yeast))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50216276((-)-dihydroguaiaretic acid | 4,4'-((2R,3R)-2,3-dim...)
Affinity DataKi:  620nMAssay Description:Inhibition of Candida albicans recombinant Nce103 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Cryptococcus neoformans var. grubii (Filobasidiell...)
Griffith University

Curated by ChEMBL
LigandPNGBDBM50216276((-)-dihydroguaiaretic acid | 4,4'-((2R,3R)-2,3-dim...)
Affinity DataKi:  810nMAssay Description:Inhibition of Cryptococcus neoformans recombinant Can2 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-carbonic anhydrase 1(Mycobacterium tuberculosis)
Griffith University

Curated by ChEMBL
LigandPNGBDBM50216276((-)-dihydroguaiaretic acid | 4,4'-((2R,3R)-2,3-dim...)
Affinity DataKi:  850nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant Rv1284 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Mycobacterium tuberculosis)
Griffith University

Curated by ChEMBL
LigandPNGBDBM50216276((-)-dihydroguaiaretic acid | 4,4'-((2R,3R)-2,3-dim...)
Affinity DataKi:  9.10E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant Rv3273 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50216276((-)-dihydroguaiaretic acid | 4,4'-((2R,3R)-2,3-dim...)
Affinity DataKi:  2.30E+5nMAssay Description:Inhibition of human recombinant alpha-carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50216276((-)-dihydroguaiaretic acid | 4,4'-((2R,3R)-2,3-dim...)
Affinity DataKi:  3.07E+5nMAssay Description:Inhibition of human recombinant alpha-carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50216276((-)-dihydroguaiaretic acid | 4,4'-((2R,3R)-2,3-dim...)
Affinity DataIC50:  3.50E+4nMAssay Description:Binding affinity to glucocorticoid receptor by GR binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50216276((-)-dihydroguaiaretic acid | 4,4'-((2R,3R)-2,3-dim...)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of human 17beta-HSD1 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estrone and NADPH by scintillation counting...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50216276((-)-dihydroguaiaretic acid | 4,4'-((2R,3R)-2,3-dim...)
Affinity DataIC50:  940nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed