BDBM50218282 (3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-4-(4-(2-oxopyridin-1(2H)-yl)benzamido)pyrrolidine-1-carboxylate::CHEMBL437555

SMILES CCOC(=O)N1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O

InChI Key InChIKey=VCOPBIUVMSEQNG-ZWKOTPCHSA-N

Data  13 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50218282   

TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218282((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218282((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)
Affinity DataKi:  0.730nMAssay Description:Inhibition of human factor 10a in presence of tripeptide substrate at 25 degCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218282((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)
Affinity DataKi:  2.60nMAssay Description:Inhibition of human factor 10a in presence of tripeptide substrate at 37 degCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218282((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)
Affinity DataKi:  7.5nMAssay Description:Inhibition of human factor 10a in presence of prothrombin at 25 degCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218282((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)
Affinity DataKi:  30nMAssay Description:Inhibition of human factor 10a in presence of saturating prothrombin at 37 degCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218282((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)
Affinity DataKi:  4.02E+3nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218282((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)
Affinity DataKi: >6.00E+3nMAssay Description:Inhibition of human plasma kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218282((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)
Affinity DataKi:  7.38E+3nMAssay Description:Inhibition of human factor 11aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218282((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)
Affinity DataKi: >1.10E+4nMAssay Description:Inhibition of human factor 7aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218282((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)
Affinity DataKi: >1.40E+4nMAssay Description:Inhibition of human urokinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218282((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)
Affinity DataKi: >2.10E+4nMAssay Description:Inhibition of human activated protein CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218282((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)
Affinity DataKi: >2.10E+4nMAssay Description:Inhibition of human tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218282((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)
Affinity DataKi: >2.20E+4nMAssay Description:Inhibition of human PlasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed