BDBM50220289 (R)-1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-propylpiperidin-2-yl)cyclopropyl 3-hydroxypyrrolidine-1-carboxylate::CHEMBL240285

SMILES CCC[C@@H]1CCC[C@@H](N1S(=O)(=O)c1ccc(Cl)cc1)C1(CC1)OC(=O)N1CC[C@@H](O)C1

InChI Key InChIKey=VCSMPFGNSZFRRW-QWFCFKBJSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50220289   

TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220289((R)-1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-propyl...)
Affinity DataIC50:  47nMAssay Description:Inhibition of gamma-secretase assessed as reduction of membrane Abeta40 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed