BDBM50220304 1-((2R,6R)-6-ethyl-1-(4-fluorophenylsulfonyl)piperidin-2-yl)cyclopropyl 8-(2-hydroxyethyl)-3,8-diaza-bicyclo[3.2.1]octane-3-carboxylate::CHEMBL236186

SMILES CC[C@@H]1CCC[C@@H](N1S(=O)(=O)c1ccc(F)cc1)C1(CC1)OC(=O)N1CC2CCC(C1)N2CCO

InChI Key InChIKey=WMZBTZZLGWZIBX-ZDTVFLJBSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50220304   

TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220304(1-((2R,6R)-6-ethyl-1-(4-fluorophenylsulfonyl)piper...)
Affinity DataIC50:  25nMAssay Description:Inhibition of gamma-secretase assessed as reduction of membrane Abeta40 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed