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BDBM50222614 2-(5-fluoro-2-(((5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)carbamoyl)phenoxy)acetic acid::CHEMBL240721

SMILES: OC(=O)COc1cc(F)ccc1C(=O)NCc1nc2cc(ccc2s1)C(F)(F)F

InChI Key: InChIKey=DPDOABOONBUWMC-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50222614   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50222614
PNG
(2-(5-fluoro-2-(((5-(trifluoromethyl)benzo[d]thiazo...)
Show SMILES OC(=O)COc1cc(F)ccc1C(=O)NCc1nc2cc(ccc2s1)C(F)(F)F
Show InChI InChI=1S/C18H12F4N2O4S/c19-10-2-3-11(13(6-10)28-8-16(25)26)17(27)23-7-15-24-12-5-9(18(20,21)22)1-4-14(12)29-15/h1-6H,7-8H2,(H,23,27)(H,25,26)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 29n/an/an/an/an/an/a



Università di Modena e Reggio Emilia

Curated by ChEMBL


Assay Description
Inhibition of aldose reductase


Bioorg Med Chem 15: 7865-77 (2007)


Article DOI: 10.1016/j.bmc.2007.08.019
BindingDB Entry DOI: 10.7270/Q2QR4WV6
More data for this
Ligand-Target Pair