BDBM50224883 7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,16-dioxa-2,4,19,21-tetraaza-tricyclo[15.3.1.0*5,10*]henicosa-1(21),5,7,9,17,19-hexaene-18-crbonitrile::CHEMBL248757

SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3

InChI Key InChIKey=AZTMYWWWILJAKW-UHFFFAOYSA-N

Data  109 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 110 hits for monomerid = 50224883   

TargetVascular endothelial growth factor receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >440nMAssay Description:Inhibition of FLT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >706nMAssay Description:Inhibition of ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >809nMAssay Description:Inhibition of FYNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi:  911nMAssay Description:Inhibition of GSK3 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi:  949nMAssay Description:Inhibition of MSK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >991nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi:  1.09E+3nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi:  1.12E+3nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeath-associated protein kinase 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.39E+3nMAssay Description:Inhibition of ZIPkMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.42E+3nMAssay Description:Inhibition of PIM2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.44E+3nMAssay Description:Inhibition of ERBB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 31(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.44E+3nMAssay Description:Inhibition of STK31More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.45E+3nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.45E+3nMAssay Description:Inhibition of BLKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.49E+3nMAssay Description:Inhibition of PRKXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNUAK family SNF1-like kinase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.50E+3nMAssay Description:Inhibition of ARK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.52E+3nMAssay Description:Inhibition of WNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.53E+3nMAssay Description:Inhibition of CDK7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.53E+3nMAssay Description:Inhibition of TBK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.53E+3nMAssay Description:Inhibition of ITKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.53E+3nMAssay Description:Inhibition of PRAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTestis-specific serine/threonine-protein kinase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.53E+3nMAssay Description:Inhibition of TSSK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi:  1.54E+3nMAssay Description:Inhibition of AMPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.55E+3nMAssay Description:Inhibition of CDK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek11(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.55E+3nMAssay Description:Inhibition of NEK11More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTestis-specific serine/threonine-protein kinase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.60E+3nMAssay Description:Inhibition of TSSK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase NLK(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.61E+3nMAssay Description:Inhibition of NLKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 33(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.64E+3nMAssay Description:Inhibition of STK33More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.64E+3nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.65E+3nMAssay Description:Inhibition of MUSKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.67E+3nMAssay Description:Inhibition of NEK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.67E+3nMAssay Description:Inhibition of MLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.67E+3nMAssay Description:Inhibition of LYNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.68E+3nMAssay Description:Inhibition of CAMK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.72E+3nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSRSF protein kinase 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.74E+3nMAssay Description:Inhibition of MSSK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.80E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.86E+3nMAssay Description:Inhibition of FGFR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.89E+3nMAssay Description:Inhibition of MSK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.94E+3nMAssay Description:Inhibition of TYK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.94E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSRSF protein kinase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi:  2.31E+3nMAssay Description:Inhibition of SRPK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >2.34E+3nMAssay Description:Inhibition of IKK betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >2.48E+3nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >2.48E+3nMAssay Description:Inhibition of TRKAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >2.70E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi:  3.01E+3nMAssay Description:Inhibition of IRAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi:  3.09E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of DYRK1AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi:  3.48E+3nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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