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BDBM50225508 CHEBI:31401::CILOSTAZOL::Cilostazol::OPC-13013::OPC-21::Pletal

SMILES: O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1

InChI Key: InChIKey=RRGUKTPIGVIEKM-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50225508   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50225508
PNG
(CHEBI:31401 | CILOSTAZOL | Cilostazol | OPC-13013 ...)
Show SMILES O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1
Show InChI InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
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n/an/a 190n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of low Km cAMP phosphodiesterase PDE III of human platelets


J Med Chem 28: 537-45 (1985)


Article DOI: 10.1021/jm50001a001
BindingDB Entry DOI: 10.7270/Q2N58MXT
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human))
BDBM50225508
PNG
(CHEBI:31401 | CILOSTAZOL | Cilostazol | OPC-13013 ...)
Show SMILES O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1
Show InChI InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
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n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human brain


J Med Chem 28: 537-45 (1985)


Article DOI: 10.1021/jm50001a001
BindingDB Entry DOI: 10.7270/Q2N58MXT
More data for this
Ligand-Target Pair
Bile salt export pump


(Homo sapiens (Human))
BDBM50225508
PNG
(CHEBI:31401 | CILOSTAZOL | Cilostazol | OPC-13013 ...)
Show SMILES O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1
Show InChI InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
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n/an/a 1.33E+5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...


Toxicol Sci 136: 216-41 (2013)


Article DOI: 10.1093/toxsci/kft176
BindingDB Entry DOI: 10.7270/Q2JM2D2D
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50225508
PNG
(CHEBI:31401 | CILOSTAZOL | Cilostazol | OPC-13013 ...)
Show SMILES O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1
Show InChI InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
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n/an/a 280n/an/an/an/an/an/a



Universit£ di Genova

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE3


J Med Chem 50: 2886-95 (2007)


Article DOI: 10.1021/jm0611511
BindingDB Entry DOI: 10.7270/Q24F1TGX
More data for this
Ligand-Target Pair
Canalicular multispecific organic anion transporter 2


(Homo sapiens (Human))
BDBM50225508
PNG
(CHEBI:31401 | CILOSTAZOL | Cilostazol | OPC-13013 ...)
Show SMILES O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1
Show InChI InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
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n/an/a 1.33E+5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...


Toxicol Sci 136: 216-41 (2013)


Article DOI: 10.1093/toxsci/kft176
BindingDB Entry DOI: 10.7270/Q2JM2D2D
More data for this
Ligand-Target Pair
Canalicular multispecific organic anion transporter 1


(Homo sapiens (Human))
BDBM50225508
PNG
(CHEBI:31401 | CILOSTAZOL | Cilostazol | OPC-13013 ...)
Show SMILES O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1
Show InChI InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
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n/an/a 1.33E+5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...


Toxicol Sci 136: 216-41 (2013)


Article DOI: 10.1093/toxsci/kft176
BindingDB Entry DOI: 10.7270/Q2JM2D2D
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Homo sapiens (Human))
BDBM50225508
PNG
(CHEBI:31401 | CILOSTAZOL | Cilostazol | OPC-13013 ...)
Show SMILES O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1
Show InChI InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
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n/an/a 9.12E+4n/an/an/an/an/an/a



ChanTest Corporation

Curated by ChEMBL


Assay Description
Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits


Sci Rep 3: (2013)


Article DOI: 10.1038/srep02100
BindingDB Entry DOI: 10.7270/Q2RB77K2
More data for this
Ligand-Target Pair
Multidrug resistance-associated protein 4


(Homo sapiens (Human))
BDBM50225508
PNG
(CHEBI:31401 | CILOSTAZOL | Cilostazol | OPC-13013 ...)
Show SMILES O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1
Show InChI InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
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n/an/a 1.66E+4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...


Toxicol Sci 136: 216-41 (2013)


Article DOI: 10.1093/toxsci/kft176
BindingDB Entry DOI: 10.7270/Q2JM2D2D
More data for this
Ligand-Target Pair