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BDBM50228850 CHEMBL168005

SMILES: COC(=O)c1cccc(Oc2ncccc2C(=O)NCc2ccccc2)c1

InChI Key: InChIKey=UPDCLFUWDJXXLO-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50228850   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228850
PNG
(CHEMBL168005)
Show SMILES COC(=O)c1cccc(Oc2ncccc2C(=O)NCc2ccccc2)c1
Show InChI InChI=1S/C21H18N2O4/c1-26-21(25)16-9-5-10-17(13-16)27-20-18(11-6-12-22-20)19(24)23-14-15-7-3-2-4-8-15/h2-13H,14H2,1H3,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228850
PNG
(CHEMBL168005)
Show SMILES COC(=O)c1cccc(Oc2ncccc2C(=O)NCc2ccccc2)c1
Show InChI InChI=1S/C21H18N2O4/c1-26-21(25)16-9-5-10-17(13-16)27-20-18(11-6-12-22-20)19(24)23-14-15-7-3-2-4-8-15/h2-13H,14H2,1H3,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.60E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair