BDBM50229343 (R)-N,N-dimethyl-2-(4-(3-methyl-4-(6-methylpyridin-3-yloxy)phenylamino)quinazolin-5-yloxy)propanamide::CHEMBL256362

SMILES C[C@@H](Oc1cccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c12)C(=O)N(C)C

InChI Key InChIKey=XNXUDGXKTVZKLB-GOSISDBHSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50229343   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50229343((R)-N,N-dimethyl-2-(4-(3-methyl-4-(6-methylpyridin...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50229343((R)-N,N-dimethyl-2-(4-(3-methyl-4-(6-methylpyridin...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50229343((R)-N,N-dimethyl-2-(4-(3-methyl-4-(6-methylpyridin...)
Affinity DataIC50:  23nMAssay Description:Inhibition of ebrB2 expressed in human MCF7 cells by autophosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50229343((R)-N,N-dimethyl-2-(4-(3-methyl-4-(6-methylpyridin...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed