BDBM50230828 5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide::CHEMBL257167::[5-(p-fluorophenyl)-2-ureido]thiophene-3-carboxamide

SMILES NC(=O)Nc1sc(cc1C(N)=O)-c1ccc(F)cc1

InChI Key InChIKey=SAYGKHKXGCPTLX-UHFFFAOYSA-N

Data  1 KI  5 IC50  2 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50230828   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50230828(5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide...)
Affinity DataKi:  5nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50230828(5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide...)
Affinity DataKd:  22nMAssay Description:Binding affinity to human JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50230828(5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide...)
Affinity DataIC50:  20nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVenus kinase receptor 2(Schistosoma mansoni)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50230828(5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide...)
Affinity DataKd:  1.60E+4nMAssay Description:Binding affinity to Schistosoma mansoni N-terminal His6-tagged full-length VKR2 kinase domain expressed in baculovirus infected Sf9 insect cells in p...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50230828(5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide...)
Affinity DataIC50:  18nMAssay Description:Inhibition of IKKbeta (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50230828(5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50230828(5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide...)
Affinity DataIC50:  18nMAssay Description:Inhibition of IKK beta at 300 uM by K-ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50230828(5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide...)
Affinity DataIC50:  19.9nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed