BindingDB logo
myBDB logout

BDBM50233707 5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl)phenyl)furan-2-carboxamide::CHEMBL252436

SMILES: CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)N1CCN(C)CC1

InChI Key: InChIKey=VPVJZBBTXRKDKI-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50233707   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233707
PNG
(5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(4-methylp...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)N1CCN(C)CC1
Show InChI InChI=1S/C23H29N5O2/c1-17-7-9-28(10-8-17)21-15-18(27-13-11-26(2)12-14-27)3-5-20(21)25-23(29)22-6-4-19(16-24)30-22/h3-6,15,17H,7-14H2,1-2H3,(H,25,29)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233707
PNG
(5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(4-methylp...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)N1CCN(C)CC1
Show InChI InChI=1S/C23H29N5O2/c1-17-7-9-28(10-8-17)21-15-18(27-13-11-26(2)12-14-27)3-5-20(21)25-23(29)22-6-4-19(16-24)30-22/h3-6,15,17H,7-14H2,1-2H3,(H,25,29)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS


Bioorg Med Chem Lett 18: 3632-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.059
BindingDB Entry DOI: 10.7270/Q2FN173T
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233707
PNG
(5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(4-methylp...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)N1CCN(C)CC1
Show InChI InChI=1S/C23H29N5O2/c1-17-7-9-28(10-8-17)21-15-18(27-13-11-26(2)12-14-27)3-5-20(21)25-23(29)22-6-4-19(16-24)30-22/h3-6,15,17H,7-14H2,1-2H3,(H,25,29)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair