BDBM50236303 4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(trifluoromethylsulfonyl)butanamide::CHEMBL257178

SMILES Fc1ccc(cc1)-c1[nH]c2ccc(cc2c1CCCC(=O)NS(=O)(=O)C(F)(F)F)C#N

InChI Key InChIKey=GVMNNUOOILCXIW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50236303   

TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50236303(4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(tr...)
Affinity DataIC50:  87nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50236303(4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(tr...)
Affinity DataIC50:  70nMAssay Description:Antagonist activity at human cloned CXCR2 by calcium flux FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Oryctolagus cuniculus)
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50236303(4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(tr...)
Affinity DataIC50:  3.00E+3nMAssay Description:Antagonist activity at rabbit CXCR2 by neutrophil chemotaxis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed