BDBM50238182 CHEMBL4100860

SMILES COc1ccc(NC(=O)C=C)cc1Nc1cc(ccn1)-c1[nH]c(CCCO)nc1-c1ccc(F)cc1

InChI Key InChIKey=MMTJMDKKUIMADW-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50238182   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50238182(CHEMBL4100860)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of binding of [3H][D-Ala2,D-Leu5]enkephalin to Opioid receptor delta 1 in the rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50238182(CHEMBL4100860)
Affinity DataIC50:  8nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50238182(CHEMBL4100860)
Affinity DataIC50: <1nMAssay Description:Inhibition of human N-terminal GST-fused EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus using TK-substrate-biotin preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed