BDBM50239965 Bromhexine::CHEBI:77032

SMILES CN(Cc1cc(Br)cc(Br)c1N)C1CCCCC1

InChI Key InChIKey=OJGDCBLYJGHCIH-UHFFFAOYSA-N

Data  2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50239965   

TargetTransmembrane protease serine 2(Homo sapiens (Human))
Fred Hutchinson Cancer Research Center

LigandPNGBDBM50239965(Bromhexine | CHEBI:77032)
Show SMILES CN(Cc1cc(Br)cc(Br)c1N)C1CCCCC1
Show InChI InChI=1S/C14H20Br2N2/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17/h7-8,12H,2-6,9,17H2,1H3
Affinity DataIC50: 750nMAssay Description:To identify inhibitors of TMPRSS2 that may be used directly in clinical studies or as lead compounds to develop targeted drugs, we screened several c...More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50239965(Bromhexine | CHEBI:77032)
Show SMILES CN(Cc1cc(Br)cc(Br)c1N)C1CCCCC1
Show InChI InChI=1S/C14H20Br2N2/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17/h7-8,12H,2-6,9,17H2,1H3
Affinity DataIC50: 2.03E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair