BDBM50240849 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine::1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine::4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline::CHEMBL1282::IMIQUIMOD::R 837

SMILES CC(C)Cn1cnc2c(N)nc3ccccc3c12

InChI Key InChIKey=DOUYETYNHWVLEO-UHFFFAOYSA-N

Data  5 IC50  7 EC50

PDB links: 2 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50240849   

TargetToll-like receptor 7(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50240849(1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...)
Affinity DataEC50:  2.12E+3nMAssay Description:Agonist activity at human TLR7 expressed in NFkappaB-stimulated HEK293 cells assessed as induction of secreted alkaline phosphatase expression by rep...More data for this Ligand-Target Pair
TargetToll-like receptor 8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50240849(1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...)
Affinity DataEC50: >2.70E+5nMAssay Description:Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50240849(1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...)
Affinity DataEC50:  1.21E+4nMAssay Description:Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50240849(1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50240849(1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50240849(1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...)
Affinity DataIC50:  646nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50240849(1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50240849(1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...)
Affinity DataEC50:  1.14E+4nMAssay Description:Agonist activity at human TLR7 expressed in HEK cells after 8 to 12 hrs by NFkappaB/SEAP reporter gene assayMore data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50240849(1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...)
Affinity DataEC50:  1.07E+4nMAssay Description:Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50240849(1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...)
Affinity DataEC50:  6.20E+3nMAssay Description:Agonist activity at human TLR7 in HEK293 cells cotransfected with SEAP reporter gene assessed as activity of SEAP incubated for 24 hrs by quanti-blue...More data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50240849(1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...)
Affinity DataEC50:  6.80E+3nMAssay Description:Agonist activity at human TLR7 expressed in HEK-Blue cells assessed as induction of NFkappaB activation by measuring increase in SEAP level by SEAP r...More data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50240849(1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed