BDBM50243981 Beta CCM::CHEMBL453066::Methyl Beta-carboline-3 carboxylate::methyl 9H-pyrido[3,4-b]indole-3-carboxylate

SMILES COC(=O)c1cc2c(cn1)[nH]c1ccccc21

InChI Key InChIKey=UKHFPVCOXBJPIN-UHFFFAOYSA-N

Data  24 KI  6 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50243981   

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
University Clinic For Psychiatry

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
University Clinic For Psychiatry

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  0.780nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
University Clinic For Psychiatry

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
In DepthDetails PubMed
TargetGamma-aminobutyric acid (GABA) B receptor 1(Rat)
Georgetown University

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  1.40nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid (GABA) B receptor 1(Rat)
Georgetown University

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
University Clinic For Psychiatry

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human recombinant GABAA alpha1 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
University Clinic For Psychiatry

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  2.20nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
UniversitÄT Heidelberg

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  2.90nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3(Human)
UniversitÄT Heidelberg

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  4.10nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
UniversitÄT Heidelberg

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  6.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
UniversitÄT Heidelberg

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  7nMAssay Description:Binding affinity to human recombinant GABAA alpha2 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3(Human)
UniversitÄT Heidelberg

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  9.20nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  44nMAssay Description:Binding affinity to human recombinant GABAA alpha5 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid (GABA) B receptor 1(Rat)
Georgetown University

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  60nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3(Human)
UniversitÄT Heidelberg

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  72nMAssay Description:Binding affinity to human recombinant GABAA alpha3 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  76.4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  310nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4(Rat)
National Institute of Diabetes, Digestive and Kidney Diseases

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  436nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  640nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to human recombinant GABAA alpha4 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Rat)
National Institute of Diabetes, Digestive and Kidney Diseases

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  2.02E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Human)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  2.05E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Human)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  3.26E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Human)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKi:  4.40E+3nMAssay Description:Binding affinity to human recombinant GABAA alpha6 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCholecystokinin receptor type A(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Tested for its activity to inhibit the binding of [125I]-gastrin to gastric glands (gastrin) in guinea pigMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Tested for its activity to inhibit the binding of [125I]-gastrin to gastric glands (gastrin) in guinea pigMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
University Clinic For Psychiatry

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKd:  1nMAssay Description:Binding affinity to GABAA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataKd:  58nMAssay Description:Binding affinity to GABAA alpha-5-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of equine serum BChE using S-butyrylthiocholine chloride as substrate incubated for 6 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electric eel)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataIC50:  6.30E+4nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 6 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Northwest A&F University

Curated by ChEMBL
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human PDE5More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Affinity DataIC50:  1.50E+5nMAssay Description:Tested for its activity to inhibit the binding of [125I]-gastrin to gastric glands (gastrin) in guinea pigMore data for this Ligand-Target Pair
In DepthDetails Article