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BDBM50244988 5-(4-hydroxybenzylidene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-one::CHEMBL513552

SMILES: Oc1ccc(\C=C2/SC(=S)N(C2=O)c2cccc(c2)C(F)(F)F)cc1

InChI Key: InChIKey=PZGSAAGYVLUUNY-ZSOIEALJSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50244988   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM50244988
PNG
(5-(4-hydroxybenzylidene)-2-thioxo-3-(3-(trifluorom...)
Show SMILES Oc1ccc(\C=C2/SC(=S)N(C2=O)c2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C17H10F3NO2S2/c18-17(19,20)11-2-1-3-12(9-11)21-15(23)14(25-16(21)24)8-10-4-6-13(22)7-5-10/h1-9,22H/b14-8-
PDB

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Similars

Article
PubMed
n/an/a 2.40E+4n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of human wild type CFTR expressed in rat FRT cells assessed as chloride current by short-circuit current measurements


Bioorg Med Chem 16: 8187-95 (2008)


Article DOI: 10.1016/j.bmc.2008.07.044
BindingDB Entry DOI: 10.7270/Q27M07S6
More data for this
Ligand-Target Pair