BDBM50245072 4-[(1-{4-[(4-Chlorophenyl)amino]-6,7-dimethoxyquinazolin-2-yl}piperidin-4-yl)(methyl)amino]butan-1-ol::CHEMBL486656

SMILES COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCC(CC1)N(C)CCCCO

InChI Key InChIKey=FULJKBQKEUBPBM-UHFFFAOYSA-N

Data  2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50245072   

TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50245072(4-[(1-{4-[(4-Chlorophenyl)amino]-6,7-dimethoxyquin...)
Show SMILES COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCC(CC1)N(C)CCCCO
Show InChI InChI=1S/C26H34ClN5O3/c1-31(12-4-5-15-33)20-10-13-32(14-11-20)26-29-22-17-24(35-3)23(34-2)16-21(22)25(30-26)28-19-8-6-18(27)7-9-19/h6-9,16-17,20,33H,4-5,10-15H2,1-3H3,(H,28,29,30)
Affinity DataIC50: 61nMAssay Description:Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50245072(4-[(1-{4-[(4-Chlorophenyl)amino]-6,7-dimethoxyquin...)
Show SMILES COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCC(CC1)N(C)CCCCO
Show InChI InChI=1S/C26H34ClN5O3/c1-31(12-4-5-15-33)20-10-13-32(14-11-20)26-29-22-17-24(35-3)23(34-2)16-21(22)25(30-26)28-19-8-6-18(27)7-9-19/h6-9,16-17,20,33H,4-5,10-15H2,1-3H3,(H,28,29,30)
Affinity DataIC50: 360nMAssay Description:Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayMore data for this Ligand-Target Pair