BDBM50246211 CHEMBL521379::N3-(4-fluoro-2,6-dimethylphenyl)-1-(3-methoxy-3-methylbutyl)-N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine

SMILES COC(C)(C)CCn1nc(Nc2c(C)cc(F)cc2C)c2cnc(Nc3ccccc3)nc12

InChI Key InChIKey=OTMWAKOGGPPKJE-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50246211   

TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50246211(CHEMBL521379 | N3-(4-fluoro-2,6-dimethylphenyl)-1-...)
Affinity DataKi:  26nMAssay Description:Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) (unknown origin) expressed in SF9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50246211(CHEMBL521379 | N3-(4-fluoro-2,6-dimethylphenyl)-1-...)
Affinity DataKi:  5.50E+3nMAssay Description:Inhibition of flag-tagged ACK1 (unknown origin) autophosphorylation expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed