BDBM50246766 CHEMBL489079::Mofegiline::US9302986, Mofegiline
SMILES NC\C(CCc1ccc(F)cc1)=C\F
InChI Key InChIKey=VXLBSYHAEKDUSU-JXMROGBWSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50246766
Affinity DataKi: 28nMAssay Description:Inhibition of human recombinant MAOB expressed in Pichia pastoris by kinetic assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10E+3nMAssay Description:Inhibition of human recombinant MAOA expressed in Pichia pastoris by kinetic assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.61E+3nMAssay Description:Inhibition of human SSAO/VAP1 measuring H2O2 production by Kitz and Wilson plot analysisMore data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Human)
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: >1.00E+4nMpH: 7.4 T: 37°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:Inhibition of rat membrane MAOBMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant MAO-B assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human DAO measuring H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of SSAO/VAP1 in mouse adipocytes measuring H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant SSAO/VAP1 assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of human recombinant MAO-A assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human SSAOMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant MAO-BMore data for this Ligand-Target Pair
Affinity DataIC50: 750nMAssay Description:Inhibition of human recombinant MAO-AMore data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMpH: 7.4Assay Description:Abdominal fat from BALB/c mice, Wistar or Sprague Dawley rats, which are tissues enriched with SSAO/VAP-1-were surgically removed. For every gram of ...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant DAOMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMpH: 7.4 T: 37°CAssay Description:Recombinant human MAO-B (0.06 mg/mL; Sigma Aldrich) was used as source of MAO-B enzyme activities. The assay was performed in a similar way as for hu...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+4nMpH: 7.4Assay Description:Briefly, HMEC cell expressing human SSAO/VAP-1 were grown in several 10 cm petri dishes, once the cells reached 100% confluency, cells were harvested...More data for this Ligand-Target Pair