BDBM50249134 4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2-amine::CHEMBL473186::RS-127445

SMILES CC(C)c1cc(nc(N)n1)-c1ccc(F)c2ccccc12

InChI Key InChIKey=ZZZQXCUPAJFVBN-UHFFFAOYSA-N

Data  11 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50249134   

Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50249134(4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
City University of New York

Curated by ChEMBL
LigandPNGBDBM50249134(4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2...)
Affinity DataKi:  0.316nMAssay Description:Binding affinity to 5HT1B receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50249134(4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2...)
Affinity DataKi:  0.320nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50249134(4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2...)
Affinity DataKi:  1.07nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50249134(4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2...)
Affinity DataKi:  398nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50249134(4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2...)
Affinity DataKi:  468nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50249134(4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2...)
Affinity DataKi:  501nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50249134(4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2...)
Affinity DataKi:  933nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50249134(4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50249134(4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50249134(4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50249134(4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2...)
Affinity DataIC50:  19nMAssay Description:Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50249134(4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2...)
Affinity DataIC50:  0.700nMAssay Description:Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed