BDBM50249406 1-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-3-(4-(pyridin-4-yloxy)phenyl)urea::CHEMBL472620::US9187470, 61

SMILES Cn1nc(cc1NC(=O)Nc1ccc(Oc2ccncc2)cc1)C(C)(C)C

InChI Key InChIKey=MHSLDASSAFCCDO-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50249406   

TargetMitogen-activated protein kinase 13(Homo sapiens (Human))
Washington University

US Patent
LigandPNGBDBM50249406(1-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-3-(4-(py...)
Affinity DataIC50:  620nMT: 2°CAssay Description:The MAPK13 blocking activity of test compounds was determined using an immobilized metal affinity polarization (IMAP) assay containing activated MAPK...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50249406(1-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-3-(4-(py...)
Affinity DataIC50:  800nMAssay Description:Inhibition of B-Raf1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Homo sapiens (Human))
Washington University

US Patent
LigandPNGBDBM50249406(1-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-3-(4-(py...)
Affinity DataIC50:  82.7nMT: 2°CAssay Description:The MAPK13 blocking activity of test compounds was determined using an immobilized metal affinity polarization (IMAP) assay containing activated MAPK...More data for this Ligand-Target Pair