BDBM50254446 (R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-yl)-2-(8-methyl-2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5,4-de]quinoxalin-1-yl)acetamide::(S)-2-(6-methyl-2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5,4-de]quinoxalin-1-yl)-N-(2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridine]-5-yl)acetamide::CHEMBL466192

SMILES CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4cc(C)cc5NC(=O)Cn(c45)c3=O)cc2C1

InChI Key InChIKey=UIJJWQFJVGLSOH-XMMPIXPASA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50254446   

TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50254446((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataKi:  0.510nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50254446((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataKi:  0.510nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50254446((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataIC50:  5.40nMAssay Description:Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50254446((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataIC50:  2.40nMAssay Description:Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50254446((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataIC50:  5.40nMAssay Description:Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50254446((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataIC50:  2.40nMAssay Description:Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed