BDBM50257750 CHEMBL494325::N-allyl-6-bromoquinazolin-4-amine::SMER28 (2)::cid_1560402

SMILES Brc1ccc2ncnc(NCC=C)c2c1

InChI Key InChIKey=BCPOLXUSCUFDGE-UHFFFAOYSA-N

Data  4 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50257750   

TargetNuclear receptor coactivator 3(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50257750(CHEMBL494325 | N-allyl-6-bromoquinazolin-4-amine |...)
Affinity DataIC50:  2.30E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetNuclear receptor coactivator 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50257750(CHEMBL494325 | N-allyl-6-bromoquinazolin-4-amine |...)
Affinity DataIC50:  6.79E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50257750(CHEMBL494325 | N-allyl-6-bromoquinazolin-4-amine |...)
Affinity DataEC50:  5.00E+4nMAssay Description:Inhibition of Huntingtin protein (unknown origin) aggregation by yeast based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHuntingtin(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50257750(CHEMBL494325 | N-allyl-6-bromoquinazolin-4-amine |...)
Affinity DataIC50:  5.36E+3nMAssay Description:Inhibition of Huntingtin protein aggregation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-homoserine lactone acylase PvdQ [A190E,F674L](Pseudomonas aeruginosa)
The Broad Institute , Cambridge, Massachusetts 02142, United States

LigandPNGBDBM50257750(CHEMBL494325 | N-allyl-6-bromoquinazolin-4-amine |...)
Affinity DataIC50:  6.50E+4nMAssay Description:The assay was performed with nine compound concentrations that ranged from 3 nM to 19.5 µM with PvdQ concentration of 20 nM. The positive contro...More data for this Ligand-Target Pair