BDBM50260153 Apamin::CHEMBL525408::Octadecapeptide venom

SMILES CC(C)C[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CSSC[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N2)NC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)[C@@H](C)O

InChI Key InChIKey=YVIIHEKJCKCXOB-STYWVVQQSA-N

Data  2 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50260153   

TargetSmall conductance calcium-activated potassium channel protein 1/2/3(Rattus norvegicus)
University Of Li£Ge

Curated by ChEMBL
LigandPNGBDBM50260153(Apamin | CHEMBL525408 | Octadecapeptide venom)
Affinity DataKi:  0.00400nMAssay Description:Displacement of [125I]apamin from Wistar rat cortical apamin-sensitive siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 1/2/3(Rattus norvegicus)
University Of Li£Ge

Curated by ChEMBL
LigandPNGBDBM50260153(Apamin | CHEMBL525408 | Octadecapeptide venom)
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition of [125I]apamin binding to calcium-activated potassium (SK) channel of rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50260153(Apamin | CHEMBL525408 | Octadecapeptide venom)
Affinity DataIC50:  0.168nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50260153(Apamin | CHEMBL525408 | Octadecapeptide venom)
Affinity DataIC50:  0.0240nMAssay Description:Inhibition of rat SK Calcium channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 1/2/3(Rattus norvegicus)
University Of Li£Ge

Curated by ChEMBL
LigandPNGBDBM50260153(Apamin | CHEMBL525408 | Octadecapeptide venom)
Affinity DataIC50:  2.04E+4nMAssay Description:Inhibition of [125I]apamin binding to calcium-activated potassium (SK) channel of rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50260153(Apamin | CHEMBL525408 | Octadecapeptide venom)
Affinity DataIC50:  0.0640nMAssay Description:Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50260153(Apamin | CHEMBL525408 | Octadecapeptide venom)
Affinity DataIC50:  0.168nMAssay Description:Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50260153(Apamin | CHEMBL525408 | Octadecapeptide venom)
Affinity DataIC50:  0.0640nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed