BDBM50260245 1,3-bis(4-(cyclopentanecarboxamido)benzamido)-2,4-bis(3-methoxy-4-(thiophene-2-carbonyloxy)phenyl)cyclobutane-1,3-dicarboxylic acid::CHEMBL510593

SMILES COc1cc(ccc1OC(=O)c1cccs1)C1C(NC(=O)c2ccc(NC(=O)C3CCCC3)cc2)(C(c2ccc(OC(=O)c3cccs3)c(OC)c2)C1(NC(=O)c1ccc(NC(=O)C2CCCC2)cc1)C(O)=O)C(O)=O

InChI Key InChIKey=NEGLAHVNMIDVPL-UHFFFAOYSA-N

Data  1 KI  1 IC50  2 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50260245   

TargetGlucagon-like peptide 1 receptor(Rattus norvegicus)
National Center for Drug Screening

Curated by ChEMBL
LigandPNGBDBM50260245(1,3-bis(4-(cyclopentanecarboxamido)benzamido)-2,4-...)
Show SMILES COc1cc(ccc1OC(=O)c1cccs1)C1C(NC(=O)c2ccc(NC(=O)C3CCCC3)cc2)(C(c2ccc(OC(=O)c3cccs3)c(OC)c2)C1(NC(=O)c1ccc(NC(=O)C2CCCC2)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C56H52N4O14S2/c1-71-41-29-35(19-25-39(41)73-51(65)43-13-7-27-75-43)45-55(53(67)68,59-49(63)33-15-21-37(22-16-33)57-47(61)31-9-3-4-10-31)46(36-20-26-40(42(30-36)72-2)74-52(66)44-14-8-28-76-44)56(45,54(69)70)60-50(64)34-17-23-38(24-18-34)58-48(62)32-11-5-6-12-32/h7-8,13-32,45-46H,3-6,9-12H2,1-2H3,(H,57,61)(H,58,62)(H,59,63)(H,60,64)(H,67,68)(H,69,70)
Affinity DataKi:  287nMAssay Description:Displacement of [125I]GLP1 from rat GLP1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetGlucagon-like peptide 1 receptor(Rattus norvegicus)
National Center for Drug Screening

Curated by ChEMBL
LigandPNGBDBM50260245(1,3-bis(4-(cyclopentanecarboxamido)benzamido)-2,4-...)
Show SMILES COc1cc(ccc1OC(=O)c1cccs1)C1C(NC(=O)c2ccc(NC(=O)C3CCCC3)cc2)(C(c2ccc(OC(=O)c3cccs3)c(OC)c2)C1(NC(=O)c1ccc(NC(=O)C2CCCC2)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C56H52N4O14S2/c1-71-41-29-35(19-25-39(41)73-51(65)43-13-7-27-75-43)45-55(53(67)68,59-49(63)33-15-21-37(22-16-33)57-47(61)31-9-3-4-10-31)46(36-20-26-40(42(30-36)72-2)74-52(66)44-14-8-28-76-44)56(45,54(69)70)60-50(64)34-17-23-38(24-18-34)58-48(62)32-11-5-6-12-32/h7-8,13-32,45-46H,3-6,9-12H2,1-2H3,(H,57,61)(H,58,62)(H,59,63)(H,60,64)(H,67,68)(H,69,70)
Affinity DataEC50:  1.08E+3nMAssay Description:Agonist activity at rat GLP1 receptor expressed in HEK293 cells assessed as cAMP releaseMore data for this Ligand-Target Pair
TargetGlucagon-like peptide 1 receptor(Rattus norvegicus)
National Center for Drug Screening

Curated by ChEMBL
LigandPNGBDBM50260245(1,3-bis(4-(cyclopentanecarboxamido)benzamido)-2,4-...)
Show SMILES COc1cc(ccc1OC(=O)c1cccs1)C1C(NC(=O)c2ccc(NC(=O)C3CCCC3)cc2)(C(c2ccc(OC(=O)c3cccs3)c(OC)c2)C1(NC(=O)c1ccc(NC(=O)C2CCCC2)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C56H52N4O14S2/c1-71-41-29-35(19-25-39(41)73-51(65)43-13-7-27-75-43)45-55(53(67)68,59-49(63)33-15-21-37(22-16-33)57-47(61)31-9-3-4-10-31)46(36-20-26-40(42(30-36)72-2)74-52(66)44-14-8-28-76-44)56(45,54(69)70)60-50(64)34-17-23-38(24-18-34)58-48(62)32-11-5-6-12-32/h7-8,13-32,45-46H,3-6,9-12H2,1-2H3,(H,57,61)(H,58,62)(H,59,63)(H,60,64)(H,67,68)(H,69,70)
Affinity DataEC50:  657nMAssay Description:Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ...More data for this Ligand-Target Pair
TargetGlucagon-like peptide 1 receptor(Rattus norvegicus)
National Center for Drug Screening

Curated by ChEMBL
LigandPNGBDBM50260245(1,3-bis(4-(cyclopentanecarboxamido)benzamido)-2,4-...)
Show SMILES COc1cc(ccc1OC(=O)c1cccs1)C1C(NC(=O)c2ccc(NC(=O)C3CCCC3)cc2)(C(c2ccc(OC(=O)c3cccs3)c(OC)c2)C1(NC(=O)c1ccc(NC(=O)C2CCCC2)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C56H52N4O14S2/c1-71-41-29-35(19-25-39(41)73-51(65)43-13-7-27-75-43)45-55(53(67)68,59-49(63)33-15-21-37(22-16-33)57-47(61)31-9-3-4-10-31)46(36-20-26-40(42(30-36)72-2)74-52(66)44-14-8-28-76-44)56(45,54(69)70)60-50(64)34-17-23-38(24-18-34)58-48(62)32-11-5-6-12-32/h7-8,13-32,45-46H,3-6,9-12H2,1-2H3,(H,57,61)(H,58,62)(H,59,63)(H,60,64)(H,67,68)(H,69,70)
Affinity DataIC50: 300nMAssay Description:Inhibition of [125I]GLP1 (7-36) amide binding to rat GLP1R expressed in HEK293 cellsMore data for this Ligand-Target Pair