BDBM50261269 CHEMBL4092191

SMILES Clc1cccc(Cl)c1-c1nc2ccnc(Nc3cc(ccn3)C#N)c2[nH]1

InChI Key InChIKey=MWEQLWHNRFPCEW-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50261269   

TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50261269(CHEMBL4092191)
Affinity DataKi:  0.700nMAssay Description:Inhibition of TYK2 (unknown origin) assessed as reduction in IL-23 induced STAT3 phosphorylation by cell based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50261269(CHEMBL4092191)
Affinity DataKi:  93nMAssay Description:Inhibition of JAK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50261269(CHEMBL4092191)
Affinity DataEC50:  35nMAssay Description:Inhibition of TYK2 (unknown origin) assessed as reduction in IL-23 induced STAT3 phosphorylation by cell based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50261269(CHEMBL4092191)
Affinity DataEC50:  7.70E+3nMAssay Description:Inhibition of JAK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed