BDBM50264389 6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)phenylamino)benzo[d]isoxazole-7-carboxamide::6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide::CHEMBL491429

SMILES FC(F)(F)c1cccc(Nc2noc3c(C(=O)Nc4cncnc4)c(Cl)ccc23)c1

InChI Key InChIKey=FEGRQUWSKADGSP-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50264389   

TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50:  353nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of Tie2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50:  75nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50:  71nMAssay Description:Inhibition of cFMS (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50:  117nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed