BDBM50265777 CHEMBL461023::N-[4-(3,4-Dihydro-6-methoxypyrazino[1,2-a]1ndol-2(1H)-yl)-butyl]isoquinoline-3-carboxamide

SMILES COc1cccc2cc3CN(CCCCNC(=O)C4=NCc5ccccc5C4)CCn3c12

InChI Key InChIKey=XLDORXGCMVUJKE-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50265777   

Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50265777(CHEMBL461023 | N-[4-(3,4-Dihydro-6-methoxypyrazino...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50265777(CHEMBL461023 | N-[4-(3,4-Dihydro-6-methoxypyrazino...)
Affinity DataKi:  33.5nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor (unknown origin) expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50265777(CHEMBL461023 | N-[4-(3,4-Dihydro-6-methoxypyrazino...)
Affinity DataKi:  164nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50265777(CHEMBL461023 | N-[4-(3,4-Dihydro-6-methoxypyrazino...)
Affinity DataKi:  1.01E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50265777(CHEMBL461023 | N-[4-(3,4-Dihydro-6-methoxypyrazino...)
Affinity DataKi:  1.84E+3nMAssay Description:Binding affinity to human ERG expressed in HEK293 cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50265777(CHEMBL461023 | N-[4-(3,4-Dihydro-6-methoxypyrazino...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed