BDBM50268165 1-Propyl-8-(4-(4-(3-trifluoromethylbenzyl)piperazine-1-sulfonyl)phenyl)-3,7-dihydropurine-2,6-dione::CHEMBL486688

SMILES CCCn1c(=O)[nH]c2nc([nH]c2c1=O)-c1ccc(cc1)S(=O)(=O)N1CCN(Cc2cccc(c2)C(F)(F)F)CC1

InChI Key InChIKey=DXXSLNCEWQRJBH-UHFFFAOYSA-N

Data  6 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50268165   

TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268165(1-Propyl-8-(4-(4-(3-trifluoromethylbenzyl)piperazi...)
Affinity DataKi:  0.775nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Institute

Curated by ChEMBL
LigandPNGBDBM50268165(1-Propyl-8-(4-(4-(3-trifluoromethylbenzyl)piperazi...)
Affinity DataKi:  273nMAssay Description:Displacement of [3H]CCPA from rat brain cortex adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268165(1-Propyl-8-(4-(4-(3-trifluoromethylbenzyl)piperazi...)
Affinity DataKi:  306nMAssay Description:Displacement of [3H]MSX-2 from human recombinant adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Institute

Curated by ChEMBL
LigandPNGBDBM50268165(1-Propyl-8-(4-(4-(3-trifluoromethylbenzyl)piperazi...)
Affinity DataKi:  1.70E+3nMAssay Description:Displacement of [3H]MSX-2 from rat brain striatum adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268165(1-Propyl-8-(4-(4-(3-trifluoromethylbenzyl)piperazi...)
Affinity DataKi:  2.61E+3nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268165(1-Propyl-8-(4-(4-(3-trifluoromethylbenzyl)piperazi...)
Affinity DataKi:  3.00E+4nMAssay Description:Displacement of [3H]PSB-11 from human recombinant adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268165(1-Propyl-8-(4-(4-(3-trifluoromethylbenzyl)piperazi...)
Affinity DataIC50:  3.56nMAssay Description:Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed