BDBM50269041 1-Benzyl-4-(4-pyridin-2-yl-piperazin-1-yl)phthalazine::CHEMBL496014

SMILES C(c1ccccc1)c1nnc(N2CCN(CC2)c2ccccn2)c2ccccc12

InChI Key InChIKey=FCTUWPXBMWNCFN-UHFFFAOYSA-N

Data  4 IC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50269041   

TargetSmoothened homolog(Mus musculus)
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50269041(1-Benzyl-4-(4-pyridin-2-yl-piperazin-1-yl)phthalaz...)
Show SMILES C(c1ccccc1)c1nnc(N2CCN(CC2)c2ccccn2)c2ccccc12
Show InChI InChI=1S/C24H23N5/c1-2-8-19(9-3-1)18-22-20-10-4-5-11-21(20)24(27-26-22)29-16-14-28(15-17-29)23-12-6-7-13-25-23/h1-13H,14-18H2
Affinity DataIC50: 643nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from mous...More data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50269041(1-Benzyl-4-(4-pyridin-2-yl-piperazin-1-yl)phthalaz...)
Show SMILES C(c1ccccc1)c1nnc(N2CCN(CC2)c2ccccn2)c2ccccc12
Show InChI InChI=1S/C24H23N5/c1-2-8-19(9-3-1)18-22-20-10-4-5-11-21(20)24(27-26-22)29-16-14-28(15-17-29)23-12-6-7-13-25-23/h1-13H,14-18H2
Affinity DataIC50: 1.24E+3nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from huma...More data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50269041(1-Benzyl-4-(4-pyridin-2-yl-piperazin-1-yl)phthalaz...)
Show SMILES C(c1ccccc1)c1nnc(N2CCN(CC2)c2ccccn2)c2ccccc12
Show InChI InChI=1S/C24H23N5/c1-2-8-19(9-3-1)18-22-20-10-4-5-11-21(20)24(27-26-22)29-16-14-28(15-17-29)23-12-6-7-13-25-23/h1-13H,14-18H2
Affinity DataIC50: 772nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 25 nM 3-chloro-4,7-difluo...More data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50269041(1-Benzyl-4-(4-pyridin-2-yl-piperazin-1-yl)phthalaz...)
Show SMILES C(c1ccccc1)c1nnc(N2CCN(CC2)c2ccccn2)c2ccccc12
Show InChI InChI=1S/C24H23N5/c1-2-8-19(9-3-1)18-22-20-10-4-5-11-21(20)24(27-26-22)29-16-14-28(15-17-29)23-12-6-7-13-25-23/h1-13H,14-18H2
Affinity DataIC50: 258nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 1 nM 3-chloro-4,7-difluor...More data for this Ligand-Target Pair