BDBM50271207 CHEMBL3719135

SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(OC(F)(F)F)c1)C1COC1

InChI Key InChIKey=UHEFRVBGJORHNV-UOIKSKOESA-N

Data  1 KI  12 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50271207   

TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271207(CHEMBL3719135)
Affinity DataKi:  3nMAssay Description:Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271207(CHEMBL3719135)
Affinity DataIC50:  129nMAssay Description:Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs in presence of 10% bovine ser...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271207(CHEMBL3719135)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human full length GST-tagged MLK3 expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271207(CHEMBL3719135)
Affinity DataIC50:  709nMAssay Description:Inhibition of recombinant His-tagged human FLT3 cytoplasmic domain expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271207(CHEMBL3719135)
Affinity DataIC50:  673nMAssay Description:Inhibition of recombinant GST-tagged human PAK4 catalytic domain expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271207(CHEMBL3719135)
Affinity DataIC50:  1.55E+3nMAssay Description:Inhibition of recombinant His-tagged human TrkA cytoplasmic domain (441 to 796 residues) expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271207(CHEMBL3719135)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length His-tagged human JNK1alpha1 expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271207(CHEMBL3719135)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length His-tagged human JNK2 (473 to end residues) expressed in baculovirus expression system at by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271207(CHEMBL3719135)
Affinity DataIC50:  5.92E+3nMAssay Description:Inhibition of recombinant human GST-tagged MLK1 expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 10(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271207(CHEMBL3719135)
Affinity DataIC50:  7.88E+3nMAssay Description:Inhibition of recombinant human full length GST-tagged MLK2 expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271207(CHEMBL3719135)
Affinity DataIC50:  195nMAssay Description:Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 13(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271207(CHEMBL3719135)
Affinity DataKd:  460nMAssay Description:Binding affinity to full length wild type human LZK (M1 to W966 residues) expressed in mammalian cells by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271207(CHEMBL3719135)
Affinity DataKd:  11nMAssay Description:Binding affinity to full length wild type human DLK (M1 to P859 residues) expressed in mammalian cells by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 12(Mus musculus)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271207(CHEMBL3719135)
Affinity DataEC50:  574nMAssay Description:Inhibition of DLK in CD-1 mouse DRG neuron assessed as axonal protection pre-incubated for 2 hrs before NGF deprivation for 16 to 20 hrs by Campenot ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 16(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271207(CHEMBL3719135)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of recombinant full length His-tagged human STK16 expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271207(CHEMBL3719135)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length GST-tagged human JNK3 expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed