BDBM50274267 4-Oxo-1-[3-(1-oxy-pyridin-3-ylethynyl)-phenyl]-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid cyclopropylamide::CHEMBL485629

SMILES [O-][n+]1cccc(c1)C#Cc1cccc(c1)-n1cc(C(=O)NC2CC2)c(=O)c2cccnc12

InChI Key InChIKey=JJWKQXNHYDJXKF-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50274267   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50274267(4-Oxo-1-[3-(1-oxy-pyridin-3-ylethynyl)-phenyl]-1,4...)
Affinity DataIC50:  6.70nMAssay Description:Intrinsic inhibition of GST-fused human PDE4A expressed in SF9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50274267(4-Oxo-1-[3-(1-oxy-pyridin-3-ylethynyl)-phenyl]-1,4...)
Affinity DataIC50:  6.57E+4nMAssay Description:Displacement of [35S]MK-499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50274267(4-Oxo-1-[3-(1-oxy-pyridin-3-ylethynyl)-phenyl]-1,4...)
Affinity DataIC50:  4.10E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50274267(4-Oxo-1-[3-(1-oxy-pyridin-3-ylethynyl)-phenyl]-1,4...)
Affinity DataIC50:  4.00E+4nMAssay Description:Competitive inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50274267(4-Oxo-1-[3-(1-oxy-pyridin-3-ylethynyl)-phenyl]-1,4...)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50274267(4-Oxo-1-[3-(1-oxy-pyridin-3-ylethynyl)-phenyl]-1,4...)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50274267(4-Oxo-1-[3-(1-oxy-pyridin-3-ylethynyl)-phenyl]-1,4...)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed