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BDBM50275055 4-{4-[2-(Phenyl-2-pyridinylamino)ethoxy]phenyl}butyric Acid::CHEMBL463785

SMILES: OC(=O)CCCc1ccc(OCCN(c2ccccc2)c2ccccn2)cc1

InChI Key: InChIKey=WQXHZCYCKCQFQP-UHFFFAOYSA-N

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50275055   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50275055
PNG
(4-{4-[2-(Phenyl-2-pyridinylamino)ethoxy]phenyl}but...)
Show SMILES OC(=O)CCCc1ccc(OCCN(c2ccccc2)c2ccccn2)cc1
Show InChI InChI=1S/C23H24N2O3/c26-23(27)11-6-7-19-12-14-21(15-13-19)28-18-17-25(20-8-2-1-3-9-20)22-10-4-5-16-24-22/h1-5,8-10,12-16H,6-7,11,17-18H2,(H,26,27)
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PubMed
n/an/an/an/a 1.20E+3n/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120-Galpha16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration b...


J Med Chem 51: 7640-4 (2009)


Article DOI: 10.1021/jm800970b
BindingDB Entry DOI: 10.7270/Q2862G9R
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50275055
PNG
(4-{4-[2-(Phenyl-2-pyridinylamino)ethoxy]phenyl}but...)
Show SMILES OC(=O)CCCc1ccc(OCCN(c2ccccc2)c2ccccn2)cc1
Show InChI InChI=1S/C23H24N2O3/c26-23(27)11-6-7-19-12-14-21(15-13-19)28-18-17-25(20-8-2-1-3-9-20)22-10-4-5-16-24-22/h1-5,8-10,12-16H,6-7,11,17-18H2,(H,26,27)
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n/an/an/an/a 2.40E+3n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay


J Med Chem 55: 4511-5 (2012)


Article DOI: 10.1021/jm300215x
BindingDB Entry DOI: 10.7270/Q21Z45P4
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50275055
PNG
(4-{4-[2-(Phenyl-2-pyridinylamino)ethoxy]phenyl}but...)
Show SMILES OC(=O)CCCc1ccc(OCCN(c2ccccc2)c2ccccn2)cc1
Show InChI InChI=1S/C23H24N2O3/c26-23(27)11-6-7-19-12-14-21(15-13-19)28-18-17-25(20-8-2-1-3-9-20)22-10-4-5-16-24-22/h1-5,8-10,12-16H,6-7,11,17-18H2,(H,26,27)
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PubMed
n/an/an/an/a 9.77E+3n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay


J Med Chem 55: 4511-5 (2012)


Article DOI: 10.1021/jm300215x
BindingDB Entry DOI: 10.7270/Q21Z45P4
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50275055
PNG
(4-{4-[2-(Phenyl-2-pyridinylamino)ethoxy]phenyl}but...)
Show SMILES OC(=O)CCCc1ccc(OCCN(c2ccccc2)c2ccccn2)cc1
Show InChI InChI=1S/C23H24N2O3/c26-23(27)11-6-7-19-12-14-21(15-13-19)28-18-17-25(20-8-2-1-3-9-20)22-10-4-5-16-24-22/h1-5,8-10,12-16H,6-7,11,17-18H2,(H,26,27)
PDB

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Article
PubMed
n/an/an/an/a 1.90E+4n/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay


J Med Chem 51: 7640-4 (2009)


Article DOI: 10.1021/jm800970b
BindingDB Entry DOI: 10.7270/Q2862G9R
More data for this
Ligand-Target Pair