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BDBM50276347 (+/-)-1,1,1-trifluoro-3-(2-(3-(1,1,2,2-tetrafluoroethoxy)phenyl)-5-(3-(trifluoromethoxy)phenyl)-3,4-dihydroquinolin-1(2H)-yl)propan-2-ol::1,1,1-trifluoro-3-(2-(2-(1,1,2,2-tetrafluoroethoxy) phenyl)-5-(3-(trifluoromethoxy)phenyl)-3,4-dihydroquinolin-1(2H)-yl)propan-2-ol::1,1,1-trifluoro-3-(2-(2-(1,1,2,2-tetrafluoroethoxy)phenyl)-5-(3-(trifluoromethoxy)phenyl)-3,4-dihydroquinolin-1(2H)-yl)propan-2-ol::1,1,1-trifluoro-3-(2-(3-(1,1,2,2 -tetrafluoroethoxy)phenyl)-5-(3-(trifluoromethoxy)phenyl)-3,4-dihydroquinolin-1(2H)-yl)propan-2-ol::1,1,1-trifluoro-3-(2-(3-(1,1,2,2-tetrafluoroethoxy)phenyl)-5-(3-(trifluoromethoxy)phenyl)-3,4-dihydroquinolin-1(2H)-yl)propan-2-ol::CHEMBL479339

SMILES: OC(CN1C(CCc2c1cccc2-c1cccc(OC(F)(F)F)c1)c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F

InChI Key: InChIKey=GUUGXBLNGYDANT-UHFFFAOYNA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50276347   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50276347
PNG
((+/-)-1,1,1-trifluoro-3-(2-(3-(1,1,2,2-tetrafluoro...)
Show SMILES OC(CN1C(CCc2c1cccc2-c1cccc(OC(F)(F)F)c1)c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F
Show InChI InChI=1/C27H21F10NO3/c28-24(29)26(33,34)40-17-6-2-5-16(13-17)21-11-10-20-19(15-4-1-7-18(12-15)41-27(35,36)37)8-3-9-22(20)38(21)14-23(39)25(30,31)32/h1-9,12-13,21,23-24,39H,10-11,14H2
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Article
PubMed
n/an/a 45n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CETP (unknown origin)-mediated transfer of [3H]cholesteryl ester from HDL donar particles to LDL acceptor particles


J Med Chem 52: 1768-72 (2009)


Article DOI: 10.1021/jm801319d
BindingDB Entry DOI: 10.7270/Q2QZ29VG
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50276347
PNG
((+/-)-1,1,1-trifluoro-3-(2-(3-(1,1,2,2-tetrafluoro...)
Show SMILES OC(CN1C(CCc2c1cccc2-c1cccc(OC(F)(F)F)c1)c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F
Show InChI InChI=1/C27H21F10NO3/c28-24(29)26(33,34)40-17-6-2-5-16(13-17)21-11-10-20-19(15-4-1-7-18(12-15)41-27(35,36)37)8-3-9-22(20)38(21)14-23(39)25(30,31)32/h1-9,12-13,21,23-24,39H,10-11,14H2
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n/an/a 300n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma derived CETP


Bioorg Med Chem Lett 19: 2456-60 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.051
BindingDB Entry DOI: 10.7270/Q2W37W6T
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50276347
PNG
((+/-)-1,1,1-trifluoro-3-(2-(3-(1,1,2,2-tetrafluoro...)
Show SMILES OC(CN1C(CCc2c1cccc2-c1cccc(OC(F)(F)F)c1)c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F
Show InChI InChI=1/C27H21F10NO3/c28-24(29)26(33,34)40-17-6-2-5-16(13-17)21-11-10-20-19(15-4-1-7-18(12-15)41-27(35,36)37)8-3-9-22(20)38(21)14-23(39)25(30,31)32/h1-9,12-13,21,23-24,39H,10-11,14H2
PDB
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Reactome pathway
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UniProtKB/SwissProt

B.MOAD
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CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma derived CETP


Bioorg Med Chem Lett 19: 2456-60 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.051
BindingDB Entry DOI: 10.7270/Q2W37W6T
More data for this
Ligand-Target Pair