BDBM502765 (2S,6R)-4-(4-amino-5-cyanopyrimidin-2-yl)-N-[2-(1- benzylpiperidin-4-yl)ethyl]-2,6-dimethylpiperazine-1-carboxamide::US11033539, Cpd. No. 4-54::US11033539, Cpd. No. 5-14

SMILES C[C@H]1CN(C[C@@H](C)N1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ncc(C#N)c(N)n1

InChI Key InChIKey=DKUCUGLBSZGZIE-BGYRXZFFSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 502765   

TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM502765((2S,6R)-4-(4-amino-5-cyanopyrimidin-2-yl)-N-[2-(1-...)
Affinity DataKi: <10nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM502765((2S,6R)-4-(4-amino-5-cyanopyrimidin-2-yl)-N-[2-(1-...)
Affinity DataKi: <10nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM502765((2S,6R)-4-(4-amino-5-cyanopyrimidin-2-yl)-N-[2-(1-...)
Affinity DataKi: >100nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM502765((2S,6R)-4-(4-amino-5-cyanopyrimidin-2-yl)-N-[2-(1-...)
Affinity DataKi: >100nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM502765((2S,6R)-4-(4-amino-5-cyanopyrimidin-2-yl)-N-[2-(1-...)
Affinity DataKi: >100nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM502765((2S,6R)-4-(4-amino-5-cyanopyrimidin-2-yl)-N-[2-(1-...)
Affinity DataKi: >100nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM502765((2S,6R)-4-(4-amino-5-cyanopyrimidin-2-yl)-N-[2-(1-...)
Affinity DataKi:  550nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM502765((2S,6R)-4-(4-amino-5-cyanopyrimidin-2-yl)-N-[2-(1-...)
Affinity DataKi:  550nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM502765((2S,6R)-4-(4-amino-5-cyanopyrimidin-2-yl)-N-[2-(1-...)
Affinity DataKi:  550nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM502765((2S,6R)-4-(4-amino-5-cyanopyrimidin-2-yl)-N-[2-(1-...)
Affinity DataKi:  550nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent