BDBM50277143 CHR 2797::CHR-2797::Tosedostat

SMILES CC(C)C[C@H]([C@H](O)C(=O)NO)C(=O)N[C@H](C(=O)OC1CCCC1)c1ccccc1

InChI Key InChIKey=FWFGIHPGRQZWIW-SQNIBIBYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50277143   

TargetAminopeptidase N(Homo sapiens (Human))
Monash University

Curated by ChEMBL
LigandPNGBDBM50277143(CHR 2797 | CHR-2797 | Tosedostat)
Affinity DataKi:  1.18E+3nMAssay Description:Inhibition of soluble human APN ectodomain stably expressed in HEK293 GnTI(-) cells using H-Leu-NHMec as substrate preincubated for 10 mins followed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Homo sapiens (Human))
Monash University

Curated by ChEMBL
LigandPNGBDBM50277143(CHR 2797 | CHR-2797 | Tosedostat)
Affinity DataIC50:  680nMAssay Description:Inhibition of recombinant human C-terminal His10-tagged APN (Lys69 to Lys967 residues) using Ala-AMC as substrate measured for 30 mins by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Monash University

Curated by ChEMBL
LigandPNGBDBM50277143(CHR 2797 | CHR-2797 | Tosedostat)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of MMP9 (unknown origin) using QF-24 as substrate preincubated for 1 hr followed by substrate addition and measured at 1 min interval for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPuromycin-sensitive aminopeptidase(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50277143(CHR 2797 | CHR-2797 | Tosedostat)
Affinity DataIC50:  260nMAssay Description:Inhibition of recombinant human N-terminal His6-MBP-tagged PSA expressed in Escherichia coli BL21 STAR (DE3) using 4-Ala-MNA as substrate measured fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Monash University

Curated by ChEMBL
LigandPNGBDBM50277143(CHR 2797 | CHR-2797 | Tosedostat)
Affinity DataIC50:  190nMAssay Description:Inhibition of MMP2 (unknown origin) using QF-24 as substrate preincubated for 1 hr followed by substrate addition and measured at 1 min interval for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed