BDBM50277143 CHR 2797::CHR-2797::Tosedostat
SMILES CC(C)C[C@H]([C@H](O)C(=O)NO)C(=O)N[C@H](C(=O)OC1CCCC1)c1ccccc1
InChI Key InChIKey=FWFGIHPGRQZWIW-SQNIBIBYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50277143
Affinity DataKi: 1.18E+3nMAssay Description:Inhibition of soluble human APN ectodomain stably expressed in HEK293 GnTI(-) cells using H-Leu-NHMec as substrate preincubated for 10 mins followed ...More data for this Ligand-Target Pair
Affinity DataIC50: 680nMAssay Description:Inhibition of recombinant human C-terminal His10-tagged APN (Lys69 to Lys967 residues) using Ala-AMC as substrate measured for 30 mins by fluorescenc...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of MMP9 (unknown origin) using QF-24 as substrate preincubated for 1 hr followed by substrate addition and measured at 1 min interval for ...More data for this Ligand-Target Pair
TargetPuromycin-sensitive aminopeptidase(Homo sapiens (Human))
University Of Minnesota
Curated by ChEMBL
University Of Minnesota
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human N-terminal His6-MBP-tagged PSA expressed in Escherichia coli BL21 STAR (DE3) using 4-Ala-MNA as substrate measured fo...More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of MMP2 (unknown origin) using QF-24 as substrate preincubated for 1 hr followed by substrate addition and measured at 1 min interval for ...More data for this Ligand-Target Pair