BDBM50280395 CHEMBL4171480

SMILES C[C@@H]1CCc2c(Br)c(F)c(Br)cc2N1C=O

InChI Key InChIKey=ZZLQPWXVZCPUGC-ZCFIWIBFSA-N

Data  5 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50280395   

TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
Institute For Research In Cancer And Allied Diseases

Curated by ChEMBL
LigandPNGBDBM50280395(CHEMBL4171480)
Affinity DataIC50:  2.23E+4nMAssay Description:Inhibition of recombinant human GST-tagged EPAC2 expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine nucleotide exchange ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute For Research In Cancer And Allied Diseases

Curated by ChEMBL
LigandPNGBDBM50280395(CHEMBL4171480)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of recombinant human GST-tagged EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute For Research In Cancer And Allied Diseases

Curated by ChEMBL
LigandPNGBDBM50280395(CHEMBL4171480)
Affinity DataIC50:  5.50E+3nMAssay Description:Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute For Research In Cancer And Allied Diseases

Curated by ChEMBL
LigandPNGBDBM50280395(CHEMBL4171480)
Affinity DataKd:  7.57E+5nMAssay Description:Binding affinity to human EPAC1 cAMP binding domain (149 to 318 residues) in presence of human serum albumin by [15N-1H]HSQC spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
Institute For Research In Cancer And Allied Diseases

Curated by ChEMBL
LigandPNGBDBM50280395(CHEMBL4171480)
Affinity DataIC50:  1.70E+4nMAssay Description:Antagonist activity at recombinant full length EPAC2 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute For Research In Cancer And Allied Diseases

Curated by ChEMBL
LigandPNGBDBM50280395(CHEMBL4171480)
Affinity DataKd:  1.24E+5nMAssay Description:Binding affinity to human EPAC1 cAMP binding domain (149 to 318 residues) by [15N-1H]HSQC spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute For Research In Cancer And Allied Diseases

Curated by ChEMBL
LigandPNGBDBM50280395(CHEMBL4171480)
Affinity DataIC50:  4.20E+3nMAssay Description:Antagonist activity at recombinant human GST-fused EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta (DE3) assessed as inhibition of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed