BDBM50283311 2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonylaminosulphonyl)-biphenyl-4-ylmethyl)-6-(2-pyridylcarbonylamino)-3H-quinazolin-4-one::CHEMBL74144

SMILES CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C

InChI Key InChIKey=ARHOSTGQGGKVFS-UHFFFAOYSA-N

Data  6 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50283311   

TargetType-1 angiotensin II receptor(RABBIT)
TBA

Curated by ChEMBL
LigandPNGBDBM50283311(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H34FN5O6S/c1-4-32-39-29-15-14-25(38-33(42)30-10-7-8-17-37-30)20-27(29)34(43)41(32)21-24-13-12-23(19-28(24)36)26-9-5-6-11-31(26)48(45,46)40-35(44)47-18-16-22(2)3/h5-15,17,19-20,22H,4,16,18,21H2,1-3H3,(H,38,42)(H,40,44)
Affinity DataIC50: 2.30nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283311(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H34FN5O6S/c1-4-32-39-29-15-14-25(38-33(42)30-10-7-8-17-37-30)20-27(29)34(43)41(32)21-24-13-12-23(19-28(24)36)26-9-5-6-11-31(26)48(45,46)40-35(44)47-18-16-22(2)3/h5-15,17,19-20,22H,4,16,18,21H2,1-3H3,(H,38,42)(H,40,44)
Affinity DataIC50: 85nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membraneMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50283311(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H34FN5O6S/c1-4-32-39-29-15-14-25(38-33(42)30-10-7-8-17-37-30)20-27(29)34(43)41(32)21-24-13-12-23(19-28(24)36)26-9-5-6-11-31(26)48(45,46)40-35(44)47-18-16-22(2)3/h5-15,17,19-20,22H,4,16,18,21H2,1-3H3,(H,38,42)(H,40,44)
Affinity DataIC50: 1.30nMAssay Description:In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-2 angiotensin II receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283311(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H34FN5O6S/c1-4-32-39-29-15-14-25(38-33(42)30-10-7-8-17-37-30)20-27(29)34(43)41(32)21-24-13-12-23(19-28(24)36)26-9-5-6-11-31(26)48(45,46)40-35(44)47-18-16-22(2)3/h5-15,17,19-20,22H,4,16,18,21H2,1-3H3,(H,38,42)(H,40,44)
Affinity DataIC50: 37nMAssay Description:In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-2 angiotensin II receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50283311(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H34FN5O6S/c1-4-32-39-29-15-14-25(38-33(42)30-10-7-8-17-37-30)20-27(29)34(43)41(32)21-24-13-12-23(19-28(24)36)26-9-5-6-11-31(26)48(45,46)40-35(44)47-18-16-22(2)3/h5-15,17,19-20,22H,4,16,18,21H2,1-3H3,(H,38,42)(H,40,44)
Affinity DataIC50: 1.80nMAssay Description:In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-2 angiotensin II receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50283311(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H34FN5O6S/c1-4-32-39-29-15-14-25(38-33(42)30-10-7-8-17-37-30)20-27(29)34(43)41(32)21-24-13-12-23(19-28(24)36)26-9-5-6-11-31(26)48(45,46)40-35(44)47-18-16-22(2)3/h5-15,17,19-20,22H,4,16,18,21H2,1-3H3,(H,38,42)(H,40,44)
Affinity DataIC50: 0.630nMAssay Description:In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membraneMore data for this Ligand-Target Pair
In DepthDetails Article