BDBM50289291 2-Hydroxy-methylolanzapine::CHEMBL100454::[10-(4-Methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulen-2-yl]-methanol

SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2sc(CO)cc12

InChI Key InChIKey=FPDIERBPQFAFSI-UHFFFAOYSA-N

Data  8 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50289291   

TargetHistamine H1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289291(2-Hydroxy-methylolanzapine | CHEMBL100454 | [10-(4...)
Affinity DataKi:  6nMAssay Description:In vitro binding affinity of compound against histamine H1 neuronal receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289291(2-Hydroxy-methylolanzapine | CHEMBL100454 | [10-(4...)
Affinity DataKi:  12nMAssay Description:In vitro binding affinity of compound against Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 2A/2B/2C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289291(2-Hydroxy-methylolanzapine | CHEMBL100454 | [10-(4...)
Affinity DataKi:  18nMAssay Description:In vitro binding affinity of compound against neuronal 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289291(2-Hydroxy-methylolanzapine | CHEMBL100454 | [10-(4...)
Affinity DataKi:  22nMAssay Description:In vitro binding affinity of compound against neuronal Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails Article
TargetD(1A) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289291(2-Hydroxy-methylolanzapine | CHEMBL100454 | [10-(4...)
Affinity DataKi:  66nMAssay Description:In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1More data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289291(2-Hydroxy-methylolanzapine | CHEMBL100454 | [10-(4...)
Affinity DataKi:  501nMAssay Description:In vitro binding affinity of compound against muscarinic neuronal receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289291(2-Hydroxy-methylolanzapine | CHEMBL100454 | [10-(4...)
Affinity DataKi:  783nMAssay Description:In vitro binding affinity of compound against neuronal alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289291(2-Hydroxy-methylolanzapine | CHEMBL100454 | [10-(4...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory concentration required to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II...More data for this Ligand-Target Pair
In DepthDetails Article
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50289291(2-Hydroxy-methylolanzapine | CHEMBL100454 | [10-(4...)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of human ERG channel in HEK293 cells by voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed