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BDBM50291327 CHEBI:68023::CUDRAFLAVONE C::Cudraflavone C

SMILES: [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])cc2oc(-c3ccc(-[#8])cc3-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c(=O)c2c1-[#8]

InChI Key: InChIKey=MUUDYSFWQUSAOO-UHFFFAOYSA-N

Data: 1 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50291327   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50291327
PNG
(CHEBI:68023 | CUDRAFLAVONE C | Cudraflavone C)
Show SMILES CC(C)=CCc1c(O)cc2oc(-c3ccc(O)cc3O)c(CC=C(C)C)c(=O)c2c1O
Show InChI InChI=1S/C25H26O6/c1-13(2)5-8-16-20(28)12-21-22(23(16)29)24(30)18(9-6-14(3)4)25(31-21)17-10-7-15(26)11-19(17)27/h5-7,10-12,26-29H,8-9H2,1-4H3
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Article
PubMed
n/an/a 260n/an/an/an/an/an/a



Sun Yat-sen University

Curated by ChEMBL


Assay Description
Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...


Eur J Med Chem 144: 758-766 (2018)


Article DOI: 10.1016/j.ejmech.2017.12.057
BindingDB Entry DOI: 10.7270/Q2TT4TG2
More data for this
Ligand-Target Pair