BDBM50297171 CHEMBL551735::N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}-2-[1-(2-hydroxybenzoyl)piperidin-4-ylidene]acetamide

SMILES [#8]-c1ccccc1-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]/[#6](=O)-[#7]-[#6@@H]-1-[#6]-[#6]-[#7](-[#6]-c2ccc3cc(F)ccc3c2)-[#6]-1

InChI Key InChIKey=TVBOHVNCFNQWSW-RUZDIDTESA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50297171   

TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297171(CHEMBL551735 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells by functional inhibition curve analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297171(CHEMBL551735 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Affinity DataIC50:  8.40nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable C-C chemokine receptor type 3(Mus musculus)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297171(CHEMBL551735 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Affinity DataIC50:  230nMAssay Description:Inhibition of mouse CCR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297171(CHEMBL551735 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed