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BDBM50298446 5-(5-((S)-2-amino-3-(1H-indol-3-yl)propoxy)pyridin-3-yl)-3-(4,5-dimethylfuran-2-yl)indolin-2-one::CHEMBL577797

SMILES: Cc1cc(oc1C)C1C(=O)Nc2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1

InChI Key: InChIKey=DLZWCMAHCZVYJE-RBQQCVMASA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50298446   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM50298446
PNG
(5-(5-((S)-2-amino-3-(1H-indol-3-yl)propoxy)pyridin...)
Show SMILES Cc1cc(oc1C)C1C(=O)Nc2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C30H28N4O3/c1-17-9-28(37-18(17)2)29-25-12-19(7-8-27(25)34-30(29)35)20-11-23(15-32-13-20)36-16-22(31)10-21-14-33-26-6-4-3-5-24(21)26/h3-9,11-15,22,29,33H,10,16,31H2,1-2H3,(H,34,35)/t22-,29?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of Akt


Eur J Med Chem 44: 4090-7 (2009)


Article DOI: 10.1016/j.ejmech.2009.04.050
BindingDB Entry DOI: 10.7270/Q2GT5N74
More data for this
Ligand-Target Pair