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BDBM50298479 (S)-1-(4-fluoro-3-methylphenyl)-3-(5-(3-methyl-1H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-3-yloxy)propan-2-amine::CHEMBL573359

SMILES: Cc1n[nH]c2cnc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(F)c(C)c2)c1

InChI Key: InChIKey=FBUXWNVDUZTLKE-KRWDZBQOSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50298479   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM50298479
PNG
((S)-1-(4-fluoro-3-methylphenyl)-3-(5-(3-methyl-1H-...)
Show SMILES Cc1n[nH]c2cnc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(F)c(C)c2)c1
Show InChI InChI=1S/C22H22FN5O/c1-13-5-15(3-4-20(13)23)6-17(24)12-29-18-7-16(9-25-10-18)21-8-19-14(2)27-28-22(19)11-26-21/h3-5,7-11,17H,6,12,24H2,1-2H3,(H,27,28)/t17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.5n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of Akt


Eur J Med Chem 44: 4090-7 (2009)


Article DOI: 10.1016/j.ejmech.2009.04.050
BindingDB Entry DOI: 10.7270/Q2GT5N74
More data for this
Ligand-Target Pair