BDBM50300033 CHEMBL585180::N2,N2-diethyl-6,7-dimethoxy-N4-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine

SMILES CCN(CC)c1nc(NC2CCN(C)CC2)c2cc(OC)c(OC)cc2n1

InChI Key InChIKey=YMSMSNAIHUSOEZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50300033   

TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300033(CHEMBL585180 | N2,N2-diethyl-6,7-dimethoxy-N4-(1-m...)
Affinity DataIC50:  910nMAssay Description:Inhibition of G9a by Thioglo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300033(CHEMBL585180 | N2,N2-diethyl-6,7-dimethoxy-N4-(1-m...)
Affinity DataIC50:  6.50E+6nMAssay Description:Inhibition of methyl transferase activity of G9a assessed as inhibition of H3K9 methylation by chemiluminescence based oxygen tunneling assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300033(CHEMBL585180 | N2,N2-diethyl-6,7-dimethoxy-N4-(1-m...)
Affinity DataIC50:  343nMAssay Description:Inhibition of human G9a catalytic domain (913 to 1193 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated H3 (1 to 25 residues) as ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300033(CHEMBL585180 | N2,N2-diethyl-6,7-dimethoxy-N4-(1-m...)
Affinity DataIC50:  9.10E+5nMAssay Description:Activity at methyl transferase activity G9a by enzyme coupled S-adenocylehomocystein detection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50300033(CHEMBL585180 | N2,N2-diethyl-6,7-dimethoxy-N4-(1-m...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human GLP catalytic domain (951 to 1235 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated H3 (1 to 25 residues) as ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300033(CHEMBL585180 | N2,N2-diethyl-6,7-dimethoxy-N4-(1-m...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of G9a by Alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed