BDBM50300145 (S)-5-Chloro-1-(cyclopropyl-2-methoxyethyl)-3-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]pyrazin-2(1H)-one::(S)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino)pyrazin-2(1H)-one::CHEMBL574852

SMILES COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O

InChI Key InChIKey=CBVDPVDNACOCTI-CYBMUJFWSA-N

Data  3 IC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50300145   

TargetCorticotropin-releasing factor receptor 1(Rattus norvegicus (rat))
Bristol-Myers Squibb Co.

Curated by ChEMBL
LigandPNGBDBM50300145((S)-5-Chloro-1-(cyclopropyl-2-methoxyethyl)-3-[6-(...)
Show SMILES COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O
Show InChI InChI=1S/C18H21ClF2N4O3/c1-9-6-12(10(2)22-16(9)28-18(20)21)23-15-17(26)25(7-14(19)24-15)13(8-27-3)11-4-5-11/h6-7,11,13,18H,4-5,8H2,1-3H3,(H,23,24)/t13-/m1/s1
Affinity DataIC50: 0.240nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenate by binding titration assayMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1(Rattus norvegicus (rat))
Bristol-Myers Squibb Co.

Curated by ChEMBL
LigandPNGBDBM50300145((S)-5-Chloro-1-(cyclopropyl-2-methoxyethyl)-3-[6-(...)
Show SMILES COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O
Show InChI InChI=1S/C18H21ClF2N4O3/c1-9-6-12(10(2)22-16(9)28-18(20)21)23-15-17(26)25(7-14(19)24-15)13(8-27-3)11-4-5-11/h6-7,11,13,18H,4-5,8H2,1-3H3,(H,23,24)/t13-/m1/s1
Affinity DataIC50: 0.290nMAssay Description:Displacement of [125I]Tyr-ovine-CRF from CRF1 receptor in rat frontal cortex homogenate after 2 hrs by gamma counting analysisMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1(Rattus norvegicus (rat))
Bristol-Myers Squibb Co.

Curated by ChEMBL
LigandPNGBDBM50300145((S)-5-Chloro-1-(cyclopropyl-2-methoxyethyl)-3-[6-(...)
Show SMILES COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O
Show InChI InChI=1S/C18H21ClF2N4O3/c1-9-6-12(10(2)22-16(9)28-18(20)21)23-15-17(26)25(7-14(19)24-15)13(8-27-3)11-4-5-11/h6-7,11,13,18H,4-5,8H2,1-3H3,(H,23,24)/t13-/m1/s1
Affinity DataIC50: 0.240nMAssay Description:Displacement of [125I]Tyr-ovine-CRF from CRF1 receptor in rat frontal cortex homogenate by gamma countingMore data for this Ligand-Target Pair