BDBM50301356 CHEMBL585927::N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-4-(methylamino)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide

SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1

InChI Key InChIKey=DSTDNBAORRODRL-UHFFFAOYSA-N

Data  9 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50301356   

TargetProtein-tyrosine kinase 2-beta(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataEC50:  10nMAssay Description:Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in osteocalcin levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human Pyk2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataEC50:  10nMAssay Description:Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in alkaline phosphatase levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataEC50:  10nMAssay Description:Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Jak1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of human FAK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Jak3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of TYK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PKRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human PyK2 Y402 autophosphorylation expressed in 293T cells by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Jak2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed