BDBM50302249 (R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)-1,3-dioxoisoindolin-2-yl)butyl)thiophene-2-sulfonamide::CHEMBL566433

SMILES CCN1CCN(CC1)c1cccc2C(=O)N([C@H](CCCNS(=O)(=O)c3cccs3)c3ccc(OC)c(OC)c3)C(=O)c12

InChI Key InChIKey=ZCTNRDFMOMOCAX-HSZRJFAPSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50302249   

TargetUrotensin-2 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50302249((R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-ethylpipera...)
Affinity DataKi:  35nMAssay Description:Displacement of [125I]urotensin 2 from urotensin 2 receptor in human RMS13 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrotensin-2 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50302249((R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-ethylpipera...)
Affinity DataIC50:  150nMAssay Description:Antagonist activity at urotensin 2 receptor in human RMS13 cells assessed as inhibition of urotensin 2-induced intracellular calcium mobilization aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrotensin-2 receptor(RAT)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50302249((R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-ethylpipera...)
Affinity DataIC50:  4.80nMAssay Description:Antagonist activity at rat urotensin 2 receptor expressed in CHOK1 cells assessed as inhibition of urotensin 2-induced intracellular calcium mobiliza...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed